Will the next COVID VOC be milder than Omicron?

Related question on Metaculus:

• Will the Omicron variant be more lethal than Delta?

There have been major variants of SARS-CoV-2 that have had increased transmissibility and severity, leading to new waves of the pandemic, primarily alpha, beta and delta. Meanwhile, Omicron so far appears to be more transmissible, and better able to evade vaccination, but less severe. This has lead to claims that this is a natural course for viral evolution, and we should expect subsequent variants to continue the trend of optimising for transmissibility over severity.

Will the next Variant of Concern (VOC) of SARS-CoV-2, assigned a Greek letter label,be less deadly than Omicron?